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Noceravide Kit for the Preparation of Technetium-99m Duramycin for Injection is a radiopharmaceutical diagnostic agent for the detection of coincidentally externalized and exposed phosphatidylethanolamine (PE). Noceravide is indicated for the detection of pathophysiologic cell death and tissue damage in the forms of apoptosis (programmed cell death/cell suicide) and necrosis (nonspecific cell death). Noceravide has been used thus far in many applications including the evaluation of apoptosis and necrosis post-exposure to radioactivity and cytotoxic chemical entities, as well as in cardiovascular and oncological research and development.

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One Technology - Many Diverse Applications!

One Technology - Many Diverse Applications!

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(1) Johnson SE, Ugolkov A, Haney CR, Bondarenko G, Li L, Waters EA, Bergan R, Tran A, O'Halloran TV, Mazar A, Zhao M. Whole-body Imaging of Cell Death Provides a Systemic, Minimally Invasive, Dynamic, and Near-real Time Indicator for Chemotherapeutic Drug Toxicity. Clin Cancer Res. 2019 Feb 15;25(4):1331-1342. doi: 10.1158/1078-0432.CCR-18-1846. Epub 2018 Nov 12. PMID: 30420445; PMCID: PMC6377818.

(2) Johnson SE, Li Z, Liu Y, Moulder JE, Zhao M. Whole-body imaging of high-dose ionizing irradiation-induced tissue injuries using 99mTc-duramycin. J Nucl Med. 2013 Aug;54(8):1397-403. doi: 10.2967/jnumed.112.112490. Epub 2013 Jun 26. PMID: 23804327; PMCID: PMC3894925.

(3) Zhao M, Li Z, Bugenhagen S. 99mTc-labeled duramycin as a novel phosphatidylethanolamine-binding molecular probe. J Nucl Med. 2008 Aug;49(8):1345-52. doi: 10.2967/jnumed.107.048603. Epub 2008 Jul 16. PMID: 18632826.

(4) Liu Z, Barber C, Gupta A, Wan L, Won YW, Furenlid LR, Chen Q, Desai AA, Zhao M, Bull DA, Unger EC, Martin DR. Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction. Nucl Med Biol. 2019 Mar;70:67-77. doi: 10.1016/j.nucmedbio.2019.01.004. Epub 2019 Jan 17. PMID: 30772168; PMCID: PMC6778684.

(5) Wang L, Wang F, Fang W, Johnson SE, Audi S, Zimmer M, Holly TA, Lee DC, Zhu B, Zhu H, Zhao M. The feasibility of imaging myocardial ischemic/reperfusion injury using (99m)Tc-labeled duramycin in a porcine model. Nucl Med Biol. 2015 Feb;42(2):198-204. doi: 10.1016/j.nucmedbio.2014.09.002. Epub 2014 Sep 23. PMID: 25451214; PMCID: PMC4570238.

(6) Audi S, Li Z, Capacete J, Liu Y, Fang W, Shu LG, Zhao M. Understanding the in vivo uptake kinetics of a phosphatidylethanolamine-binding agent (99m)Tc-Duramycin. Nucl Med Biol. 2012 Aug;39(6):821-5. doi: 10.1016/j.nucmedbio.2012.02.004. Epub 2012 Apr 23. PMID: 22534031; PMCID: PMC3866915.

(7) Liu Z, Larsen BT, Lerman LO, Gray BD, Barber C, Hedayat AF, Zhao M, Furenlid LR, Pak KY, Woolfenden JM. Detection of atherosclerotic plaques in ApoE-deficient mice using (99m)Tc-duramycin. Nucl Med Biol. 2016 Aug;43(8):496-505. doi: 10.1016/j.nucmedbio.2016.05.007. Epub 2016 May 19. PMID: 27236285; PMCID: PMC4947567.

(8)Zhang Y, Stevenson GD, Barber C, Furenlid LR, Barrett HH, Woolfenden JM, Zhao M, Liu Z. Imaging of rat cerebral ischemia-reperfusion injury using(99m)Tc-labeled duramycin. Nucl Med Biol. 2013 Jan;40(1):80-8. doi: 10.1016/j.nucmedbio.2012.09.004. Epub 2012 Nov 2. PMID: 23123139; PMCID: PMC3632380.

(9)Medhora M, Haworth S, Liu Y, Narayanan J, Gao F, Zhao M, Audi S, Jacobs ER, Fish BL, Clough AV. Biomarkers for Radiation Pneumonitis Using Noninvasive Molecular Imaging. J Nucl Med. 2016 Aug;57(8):1296-301. doi: 10.2967/jnumed.115.160291. Epub 2016 Mar 31. PMID: 27033892; PMCID: PMC5053021.

(10) Audi SH, Jacobs ER, Zhang X, Camara AKS, Zhao M, Medhora MM, Rizzo B, Clough AV. Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging. Shock. 2017 Oct;48(4):467-476. doi: 10.1097/SHK.0000000000000872. PMID: 28915216; PMCID: PMC5636640.

(11) Audi SH, Jacobs ER, Zhao M, Roerig DL, Haworth ST, Clough AV. In vivo detection of hyperoxia-induced pulmonary endothelial cell death using (99m)Tc-duramycin. Nucl Med Biol. 2015 Jan;42(1):46-52. doi: 10.1016/j.nucmedbio.2014.08.010. Epub 2014 Aug 19. PMID: 25218023; PMCID: PMC4383294.

(12) Elvas F, Boddaert J, Vangestel C, Pak K, Gray B, Kumar-Singh S, Staelens S, Stroobants S, Wyffels L. 99mTc-Duramycin SPECT Imaging of Early Tumor Response to Targeted Therapy: A Comparison with 18F-FDG PET. J Nucl Med. 2017 Apr;58(4):665-670. doi: 10.2967/jnumed.116.182014. Epub 2016 Nov 22. PMID: 27879368.

(13) Zhang L, Suksanpaisan L, Jiang H, DeGrado TR, Russell SJ, Zhao M, Peng KW. Dual-Isotope SPECT Imaging with NIS Reporter Gene and Duramycin to Visualize Tumor Susceptibility to Oncolytic Virus Infection. Mol Ther Oncolytics. 2019 Oct 10;15:178-185. doi: 10.1016/j.omto.2019.10.002. PMID: 31890867; PMCID: PMC6931109.

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