Frequently Asked Questions
Your Complete Guide to TITAN™ Services and Capabilities
Get answers to the most common questions about TITAN™ studies, pricing, timelines, and capabilities. Can't find what you're looking for? Contact our team directly for personalized assistance.
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[Service Tiers & Pricing] | [Technical Questions] | [Study Process]
[Custom Services] | [Business Terms] | [Customer-Specific]
PRICING & SERVICES
SERVICE TIERS & PRICING QUESTION
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Q: What are the three service tiers and how do they differ?:
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Imaging Only ($150K): High-resolution SPECT/CT imaging at Days 1, 3, 5 with detailed analysis. You receive live animals and handle internal tissue processing.
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Standard Integration ($200K): Everything in Imaging Only PLUS clinical biomarkers (CBC + CMP) and integrated "cross-talk" analysis between blood work and imaging findings.
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Comprehensive ($250K): Our flagship service. Includes everything in Standard PLUS MRI imaging, full histopathology (H&E, TUNEL), and board-certified pathologist review for a publication-quality data package
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Q: Do you offer volume pricing for multiple compounds?
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Yes. Volume pricing is designed for pipeline screening and portfolio optimization:
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10+ Compounds: 10% discount
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20+ Compounds: 25% discount
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These tiers apply whether studies are run simultaneously or spread across a 12-month development cycle.
TECHNICAL DETAILS
HOW TITAN™ WORKS
Q: How does the TITAN™ proprietary tracer detect tissue damage?
Our proprietary radiotracer Noceravide accumulates specifically in dead and/or dying tissues undergoing apoptosis and necrosis. By binding to cellular components exposed during candidate-induced tissue injury, the SPECT imaging can quantify damage throughout the body 1–3 days before traditional serum biomarkers or clinical signs appear.​
Q: Can TITAN™ detect all types of toxicity?
TITAN™ is exceptionally sensitive to cytotoxic tissue damage involving cell injury across all organ systems, including hepatotoxicity, nephrotoxicity, and cardiotoxicity. It is less effective for pure functional/behavioral changes that do not result in tissue injury (e.g., reversible biochemical shifts or electrophysiological changes).​
Q: What species and animal models do you work with?
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TITAN™ is compatible with ALL animal models
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Standard: Standard small animal models include healthy rodent mouse (ie: C57BL/6, BALB/c) and rat (ie: Sprague Dawley Wistar) models.
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Advanced: Large animals (Dog, NHP, Minipig), disease models (Tumor-bearing, aged), and demographic matrices (Male vs. Female and/or Young vs. Old).
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STUDY LOGISTICS
TIMELINE & PROCESS QUESTIONS
Q: How long does a complete TITAN™ study take?
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The total timeline is 12–14 weeks.
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Setup: 2–3 weeks (Contracting & animal ordering)
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Execution: 3 weeks (Dosing & longitudinal imaging)
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Analysis: 6–8 weeks (Image quantification, biomarkers, and final report writing)
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Expedited Analysis (4–5 weeks) available for an additional fee.​
Q: Can you run multiple studies simultaneously?
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Yes. We frequently run parallel studies for pipeline screening. This allows you to test 10+ compounds in the same 12–14 week window rather than waiting 2+ years for sequential testing.
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ADVANCED CAPABILITIES
CUSTOM SERVICES & ADD-ONS
Q: When should I consider Large Animal studies?
Large animal validation (Dog, NHP) is highly recommended for biologics development, medical devices, and high-investment assets where the FDA requires non-rodent safety profiles. These studies typically range from $400K–$1M+ but provide the highest degree of human translation.​
Q: Why include Age and/or Sex Matrices in your safety package?
The FDA’s evolving "Diversity Action Plan" increasingly requires preclinical data that reflects human population diversity. We offer Age/Sex Matrices (Young vs. Aged, Male vs. Female) to ensure your safety package is regulatory-ready for diverse clinical entries.
INTELLECTUAL PROPERTY & OWNERSHIP
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Q: Who owns the study results and the TITAN™ technology?
A: We maintain clear boundaries to protect both parties:
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The Customer: Retains full ownership of their compound and all validated study results. You have the exclusive right to use the findings for regulatory filings, publications, and patent applications.
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Durametrix: Retains all rights to the TITAN™ platform technology, proprietary tracers, imaging protocols, and analysis methodology.
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Q: What happens if a novel discovery or indication arises during the study?
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A: Our standard Master Service Agreement (MSA) is industry-friendly. We respect your ownership of your assets; in the event that a novel "Use Case" or discovery occurs via our platform, we work collaboratively with our clients to determine the optimal path forward—whether through joint ventures, licensing, or expanded development.
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Q: What deliverables do I receive at the end of the study?
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A: You receive a Comprehensive Study Report (60–100+ pages). This is a submission-ready document containing all processed data, quantitative visualizations, and mechanistic interpretations.
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Note: To protect the proprietary nature of the TITAN™ platform, Durametrix does not provide raw DICOM imaging files or unprocessed Excel datasets.
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CUSTOMER-SPECIFIC
QUESTIONS BY CUSTOMER TYPE
Q: How does TITAN™ support M&A Due Diligence?
A: Our 12–14 week timeline fits within the standard 90-day due diligence window, allowing investment firms to independently validate a biotech’s safety claims before a transaction closes.​
Q: How do CRO partnerships work?
​A: We offer White-label and Co-branded models. Your CRO can offer "Advanced Mechanistic Safety" as a premium service, while Durametrix handles the technical execution and generates the final data report.
STILL HAVE QUESTIONS?
Get Personalized Answers
Our team provides personalized guidance for your specific research needs:
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Phone Consultation (15–30 mins): Quick technical or pricing answers.
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Email Response (within 4 hours): Detailed written estimates and timeline planning.
Questions? Contact Our Scientific Team:
Phone: (414) 465-8654
Email: inquiries@durametrix.com
Our team reviews all inquiries daily. You can expect a response from a technical lead by the next business day.