top of page
PEER-REVIEWED EVIDENCE:
Scientific Validation & Publications
Globally Validated and Backed by Peer-Reviewed Research
The drug development process is often stalled by the "blind spots" between dosing and traditional histopathology. Durametrix was founded to close this gap. The TITAN™ platform and Noceravide™ provide a peer-reviewed framework for transforming preclinical development. By integrating longitudinal imaging, systemic chemistry, and gold-standard pathology, we provide a transparent and highly sensitive lens into candidate/asset behavior. Our methodology has been independently validated and is supported by peer-reviewed research published in some of the world's most respected oncology and nuclear medicine journals. The following publications represent a decade of research demonstrating how greater visibility into asset behavior can help reduce uncertainty and risk throughout preclinical development—because when you have the ability to see the total truth, you reduce the risk of clinical failure.
 

Peer-Reviewed Publications

​

  1. Johnson SE, Haney CR, Spann AN, Khurram N, Obeidin F, Lee J, Zhao M. An in vivo imaging approach for simultaneously assessing tumor response and cytotoxicity-induced tissue response in chemotherapy. Apoptosis. 2025 Jun;30(5-6):1515-1524. doi: 10.1007/s10495-025-02118-9. Epub 2025 Apr 26. PMID: 40281308; PMCID: PMC12167287.

  2. ​Ren K, Hou S, Johnson SE, Lomasney J, Haney CR, Lee J, Ge ZD, Lee DC, Goldberger JJ, Arora R, Zhao M. In Vivo Mapping of Myocardial Injury Outside the Infarct Zone: Tissue at an Intermediate Pathological State. J Am Heart Assoc. 2024 May 7;13(9):e032577. doi: 10.1161/JAHA.123.032577. Epub 2024 Apr 19. PMID: 38639350; PMCID: PMC11179872.

  3. Johnson SE, Ugolkov A, Haney CR, Bondarenko G, Li L, Waters EA, Bergan R, Tran A, O'Halloran TV, Mazar A, Zhao M. Whole-body Imaging of Cell Death Provides a Systemic, Minimally Invasive, Dynamic, and Near-real Time Indicator for Chemotherapeutic Drug Toxicity. Clin Cancer Res. 2019 Feb 15;25(4):1331-1342. doi: 10.1158/1078-0432.CCR-18-1846. Epub 2018 Nov 12. PMID: 30420445; PMCID: PMC6377818.

  4. ​Johnson SE, Li Z, Liu Y, Moulder JE, Zhao M. Whole-body imaging of high-dose ionizing irradiation-induced tissue injuries using 99mTc-duramycin. J Nucl Med. 2013 Aug;54(8):1397-403. doi: 10.2967/jnumed.112.112490. Epub 2013 Jun 26. PMID: 23804327; PMCID: PMC3894925.

  5. ​Zhao M, Li Z, Bugenhagen S. 99mTc-labeled duramycin as a novel phosphatidylethanolamine-binding molecular probe. J Nucl Med. 2008 Aug;49(8):1345-52. doi: 10.2967/jnumed.107.048603. Epub 2008 Jul 16. PMID: 18632826.

  6. ​Liu Z, Barber C, Gupta A, Wan L, Won YW, Furenlid LR, Chen Q, Desai AA, Zhao M, Bull DA, Unger EC, Martin DR. Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction. Nucl Med Biol. 2019 Mar;70:67-77. doi: 10.1016/j.nucmedbio.2019.01.004. Epub 2019 Jan 17. PMID: 30772168; PMCID: PMC6778684.

  7. Wang L, Wang F, Fang W, Johnson SE, Audi S, Zimmer M, Holly TA, Lee DC, Zhu B, Zhu H, Zhao M. The feasibility of imaging myocardial ischemic/reperfusion injury using (99m)Tc-labeled duramycin in a porcine model. Nucl Med Biol. 2015 Feb;42(2):198-204. doi: 10.1016/j.nucmedbio.2014.09.002. Epub 2014 Sep 23. PMID: 25451214; PMCID: PMC4570238.

  8. ​Audi S, Li Z, Capacete J, Liu Y, Fang W, Shu LG, Zhao M. Understanding the in vivo uptake kinetics of a phosphatidylethanolamine-binding agent (99m)Tc-Duramycin. Nucl Med Biol. 2012 Aug;39(6):821-5. doi: 10.1016/j.nucmedbio.2012.02.004. Epub 2012 Apr 23. PMID: 22534031; PMCID: PMC3866915.

  9. ​Liu Z, Larsen BT, Lerman LO, Gray BD, Barber C, Hedayat AF, Zhao M, Furenlid LR, Pak KY, Woolfenden JM. Detection of atherosclerotic plaques in ApoE-deficient mice using (99m)Tc-duramycin. Nucl Med Biol. 2016 Aug;43(8):496-505. doi: 10.1016/j.nucmedbio.2016.05.007. Epub 2016 May 19. PMID: 27236285; PMCID: PMC4947567.

  10. ​Zhang Y, Stevenson GD, Barber C, Furenlid LR, Barrett HH, Woolfenden JM, Zhao M, Liu Z. Imaging of rat cerebral ischemia-reperfusion injury using(99m)Tc-labeled duramycin. Nucl Med Biol. 2013 Jan;40(1):80-8. doi: 10.1016/j.nucmedbio.2012.09.004. Epub 2012 Nov 2. PMID: 23123139; PMCID: PMC3632380.

  11. Medhora M, Haworth S, Liu Y, Narayanan J, Gao F, Zhao M, Audi S, Jacobs ER, Fish BL, Clough AV. Biomarkers for Radiation Pneumonitis Using Noninvasive Molecular Imaging. J Nucl Med. 2016 Aug;57(8):1296-301. doi: 10.2967/jnumed.115.160291. Epub 2016 Mar 31. PMID: 27033892; PMCID: PMC5053021.

  12. ​Audi SH, Jacobs ER, Zhang X, Camara AKS, Zhao M, Medhora MM, Rizzo B, Clough AV. Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging. Shock. 2017 Oct;48(4):467-476. doi: 10.1097/SHK.0000000000000872. PMID: 28915216; PMCID: PMC5636640.

  13. ​Audi SH, Jacobs ER, Zhao M, Roerig DL, Haworth ST, Clough AV. In vivo detection of hyperoxia-induced pulmonary endothelial cell death using (99m)Tc-duramycin. Nucl Med Biol. 2015 Jan;42(1):46-52. doi: 10.1016/j.nucmedbio.2014.08.010. Epub 2014 Aug 19. PMID: 25218023; PMCID: PMC4383294.

  14. ​Elvas F, Boddaert J, Vangestel C, Pak K, Gray B, Kumar-Singh S, Staelens S, Stroobants S, Wyffels L. 99mTc-Duramycin SPECT Imaging of Early Tumor Response to Targeted Therapy: A Comparison with 18F-FDG PET. J Nucl Med. 2017 Apr;58(4):665-670. doi: 10.2967/jnumed.116.182014. Epub 2016 Nov 22. PMID: 27879368.

  15. ​Zhang L, Suksanpaisan L, Jiang H, DeGrado TR, Russell SJ, Zhao M, Peng KW. Dual-Isotope SPECT Imaging with NIS Reporter Gene and Duramycin to Visualize Tumor Susceptibility to Oncolytic Virus Infection. Mol Ther Oncolytics. 2019 Oct 10;15:178-185. doi: 10.1016/j.omto.2019.10.002. PMID: 31890867; PMCID: PMC6931109.

REDUCE THE UNCERTAINTY IN YOUR PIPELINE.

Schedule a 30-minute technical assessment to evaluate your current safety data.

WHAT'S INVOLVED IN A PRE-STUDY TECHNICAL ASSESSMENT?

Free 30-Minute Consultation

No sales pressure. Just a technical consultation from scientists who understand that data integrity is the only path to a successful IND. Evaluate your current safety data and identify where systemic imaging can provide the evidence you need to move forward—or pivot— with confidence.

  • Audit Your Pipeline: Review your compound's development stage and known target tissues.

​ 

  • Identify Blind Spots: Discuss current safety protocols and where "hidden" tissue insult might occur.

 

  • Technical Fit: Determine if TITAN™ anatomical validation is the right tool for your specific molecule.

​ 

  • Project Logistics: Provide custom timelines and a transparent investment estimate.

​ 

  • Technical Q&A: Address methodology, data-integration, and regulatory context.

PREFER TO TALK NOW?

Phone: (414) 465-8654
 

Email: inquiries@durametrix.com
 

Our team reviews all inquiries daily. You can expect a response from a technical lead by the next business day.

Durametrix   |   © 2026 by Durametrix LLC

Privacy Policy   •  Terms of Service  •   Animal Welfare Statement  •   LinkedIn

TITAN™ services and anatomical validations are provided for exploratory research and discovery purposes only. Data and findings are intended to inform internal R&D decision-making and do not constitute a formal GLP regulatory toxicology conclusion or clinical safety guarantee.

bottom of page